Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898302 | 1.00 | KDR (0.49) | KDRSYKMAPTSMN1; SMN2NPC1 | |
| SCHEMBL28824948 | 0.91 | LMNA (0.48) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL29898301 | 0.91 | LMNA (0.48) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL29898313 | 0.89 | MAPT (0.46) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL28824952 | 0.89 | MAPT (0.46) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL28824923 | 0.86 | HDAC3 (0.48) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL29898300 | 0.83 | SYK (0.44) | KDRSYKMAPTSMN1; SMN2NPC1 | |
| SCHEMBL28949528 | 0.83 | SYK (0.44) | KDRSYKMAPTSMN1; SMN2NPC1 | |
| SCHEMBL29898255 | 0.83 | MAPT (0.45) | SYKMAPTSMN1; SMN2NPC1AHR | |
| SCHEMBL28824931 | 0.83 | MAPT (0.45) | SYKMAPTSMN1; SMN2NPC1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |