Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 5/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28824927 | 0.92 | AKR1C3 (0.46) | AKR1C3AKR1C2TP53MAPTCSF1R | |
| SCHEMBL29898299 | 0.92 | AKR1C3 (0.46) | AKR1C3AKR1C2TP53MAPTCSF1R | |
| SCHEMBL28824929 | 0.90 | CSF1R (0.45) | TP53MAPTCSF1RSYKDHODH | |
| SCHEMBL28824952 | 0.88 | MAPT (0.46) | AKR1C3AKR1C2TP53MAPTCSF1R | |
| SCHEMBL29898313 | 0.88 | MAPT (0.46) | AKR1C3AKR1C2TP53MAPTCSF1R | |
| SCHEMBL28824923 | 0.83 | HDAC3 (0.48) | MAPTCSF1RSYKNPC1RAB9A | |
| SCHEMBL28824917 | 0.81 | LMNA (0.43) | MAPTCSF1RSYKDHODHMAPK10 | |
| SCHEMBL29898289 | 0.81 | LMNA (0.43) | MAPTCSF1RSYKDHODHMAPK10 | |
| SCHEMBL28824948 | 0.79 | LMNA (0.48) | MAPTCSF1RSYKDHODHNPC1 | |
| SCHEMBL29898301 | 0.79 | LMNA (0.48) | MAPTCSF1RSYKDHODHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |