Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.41 |
| ▸ | RXRA | P19793 | 10/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825437 | 0.85 | GRIN1 (0.44) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL28825467 | 0.82 | GRIN1 (0.42) | GRIN2BGRIN1RXRADRD1KCNH2 | |
| SCHEMBL28825536 | 0.80 | GRIN2B (0.37) | GRIN2BGRIN1RXRA | |
| SCHEMBL28525148 | 0.79 | NFE2L2 (0.40) | GRIN2BGRIN1 | |
| SCHEMBL28825512 | 0.77 | GRIN1 (0.42) | GRIN2BGRIN1RXRADRD1 | |
| SCHEMBL28825490 | 0.76 | GRIN2B (0.41) | GRIN2BGRIN1RXRADRD1KCNH2 | |
| SCHEMBL28825459 | 0.76 | GRIN2B (0.42) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL28949583 | 0.76 | GRIN2B (0.36) | GRIN2BGRIN1RXRA | |
| SCHEMBL28825668 | 0.75 | GRIN1 (0.43) | GRIN2BGRIN1RXRAAMY1A | |
| SCHEMBL28825619 | 0.72 | GRIN2B (0.37) | GRIN2BGRIN1RXRADRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |