Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825534 | 0.85 | GRIN2B (0.44) | GRIN1GRIN2BLMNAKMT2APOLB | |
| SCHEMBL28825529 | 0.84 | GRIN2B (0.41) | GRIN1GRIN2BRXRADRD1 | |
| SCHEMBL28825625 | 0.82 | GRIN1 (0.43) | GRIN1GRIN2BRXRA | |
| SCHEMBL28825646 | 0.82 | GRIN2B (0.41) | GRIN1GRIN2BRXRADRD1 | |
| SCHEMBL28825504 | 0.80 | ALOX5 (0.42) | GRIN1GRIN2BNTSR1LMNAMAPT | |
| SCHEMBL28825459 | 0.80 | GRIN2B (0.42) | GRIN1GRIN2BKMT2AGAARAB9A | |
| SCHEMBL28825475 | 0.79 | CYP1A1 (0.52) | NTSR1LMNAKMT2AMAPTKDM4E | |
| SCHEMBL28825677 | 0.77 | GRIN1 (0.45) | GRIN1GRIN2BMAPTKDM4EALDH1A1 | |
| SCHEMBL28825533 | 0.77 | GRIN2B (0.41) | GRIN1GRIN2BRXRADRD1 | |
| SCHEMBL28825619 | 0.76 | GRIN2B (0.37) | GRIN1GRIN2BMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |