Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 12/20 | 0.40 |
| ▸ | JAK1 | P23458 | 11/20 | 0.40 |
| ▸ | TYK2 | P29597 | 10/20 | 0.40 |
| ▸ | STAT3 | P40763 | 10/20 | 0.40 |
| ▸ | JAK3 | P52333 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662812 | 1.00 | MAPT (0.41) | MAPTLMNAJAK2JAK1TYK2 | |
| SCHEMBL28052722 | 0.89 | JAK2 (0.40) | MAPTLMNAJAK2JAK1TYK2 | |
| SCHEMBL1662461 | 0.89 | JAK2 (0.40) | MAPTLMNAJAK2JAK1TYK2 | |
| SCHEMBL612055 | 0.80 | — | — | |
| SCHEMBL23022153 | 0.77 | JAK2 (0.38) | MAPTLMNAJAK2JAK1TYK2 | |
| SCHEMBL14964510 | 0.77 | JAK2 (0.46) | MAPTLMNAJAK2JAK1TYK2 | |
| SCHEMBL19976137 | 0.77 | ALDH1A1 (0.41) | LMNAJAK2JAK1TYK2STAT3 | |
| SCHEMBL27869430 | 0.75 | — | — | |
| SCHEMBL23875201 | 0.75 | — | — | |
| SCHEMBL13826264 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666545-B | As the heterocycle Pyrazolopyrimidine analogs of JAK inhibitor | CELLZOME LTD. (GB) | 2016-04-06 | — | — | CN | disclosed |