Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15701281 | 0.81 | MAPT (0.64) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL5214366 | 0.78 | NPC1 (0.71) | KDM4ENPC1RAB9ASMN1; SMN2GRM4 | |
| SCHEMBL15701231 | 0.78 | ALDH1A1 (0.57) | KDM4ESMN1; SMN2GRM4HSD17B10MAPT | |
| SCHEMBL15707505 | 0.78 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2GRM4MAPT | |
| SCHEMBL29072630 | 0.78 | GRM4 (0.53) | KDM4ENPC1RAB9ASMN1; SMN2GRM4 | |
| SCHEMBL30580392 | 0.78 | GRM4 (0.53) | KDM4ENPC1RAB9ASMN1; SMN2GRM4 | |
| SCHEMBL15070508 | 0.77 | RAB9A (0.59) | KDM4ENPC1RAB9ASMN1; SMN2GRM4 | |
| SCHEMBL12707696 | 0.77 | P4HTM (0.67) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL15701220 | 0.76 | NPC1 (0.63) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15886252 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2GRM4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443107-B | Thiazolopyrimidine compound | F. HOFFMANN-LA ROCHE AG (CH) | 2016-04-20 | — | — | CN | claimed |
| CN-103443107-B | Thiazolopyrimidine compound | F. HOFFMANN-LA ROCHE AG (CH) | 2016-04-20 | — | — | CN | disclosed |