Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28064557 | 0.84 | HDAC11 (0.47) | SCN9ACHEK2 | |
| SCHEMBL24074547 | 0.82 | GRM2 (0.44) | KMT2ACHEK2FLT3 | |
| SCHEMBL16571054 | 0.81 | NTRK1 (0.40) | AURKATPX2CHEK1KDM4EGAA | |
| SCHEMBL16571279 | 0.80 | KDM4E (0.39) | AURKATPX2CHEK1KDM4EGAA | |
| SCHEMBL30494484 | 0.80 | HPGD (0.46) | KDM4EKMT2A | |
| SCHEMBL28064535 | 0.80 | HPGD (0.46) | KDM4EKMT2A | |
| SCHEMBL28064654 | 0.78 | IKBKB (0.39) | KMT2A | |
| SCHEMBL28207999 | 0.76 | KDM4E (0.60) | AURKATPX2KDM4EGAAKMT2A | |
| SCHEMBL28064616 | 0.73 | HRH4 (0.40) | KMT2A | |
| SCHEMBL4860862 | 0.72 | KDM4E (0.73) | KDM4EGAAKMT2AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | claimed |
| CN-105555763-A | Indole-carboxamide derivatives | HOFFMANN LA ROCHE | 2016-05-04 | — | — | CN | disclosed |