Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28069202 | 0.88 | MERTK (0.36) | KDM1ADDB1CRBNMERTKLMNA | |
| SCHEMBL9941587 | 0.78 | DDB1 (0.44) | DDB1CRBNGRM2CNR2 | |
| SCHEMBL15312555 | 0.76 | KDM4E (0.47) | MERTK | |
| Tert-Butyl Formate SCHEMBL27744214 | 0.76 | KDM1A (0.42) | KDM1ACNR2DRD2 | |
| SCHEMBL9941953 | 0.75 | PKM (0.48) | DDB1CRBNGRM2LMNACNR2 | |
| Tert-Butyl Formate SCHEMBL27940168 | 0.74 | MERTK (0.35) | KDM1ASSTR4MERTKDRD2 | |
| SCHEMBL28829369 | 0.74 | LMNA (0.35) | DDB1CRBNSSTR4GRM2LMNA | |
| SCHEMBL9941718 | 0.73 | DDB1 (0.40) | DDB1CRBNGRM2CNR2 | |
| SCHEMBL27921618 | 0.72 | DDB1 (0.37) | DDB1CRBNLMNACNR2 | |
| SCHEMBL15312469 | 0.71 | FEN1 (0.47) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103347882-B | Substituted N- (1H-indazol-4-yl) imidazo [1,2-a ] pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-05-11 | — | — | CN | disclosed |