Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Claulansine F SCHEMBL29684000 | 0.86 | ALDH1A1 (0.61) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL28829842 | 0.85 | MAPT (0.44) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| Koenimbine SCHEMBL29581663 | 0.80 | MAPT (0.69) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| Haplamine SCHEMBL30203195 | 0.72 | ALDH1A1 (1.00) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| Haplamine SCHEMBL257952 | 0.72 | ALDH1A1 (1.00) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL30929792 | 0.71 | MAPT (0.69) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL28829872 | 0.70 | MAPT (0.49) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL21256051 | 0.67 | KMT2A (0.77) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL29502491 | 0.67 | MAPT (0.72) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL18271405 | 0.66 | PIKFYVE (0.69) | KDM4EALDH1A1MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685519-B | Pyranocarbazole alkaloid derivatives and application thereof in treating Alzheimer's disease | 中国医学科学院药物研究所 | 2023-09-26 | — | — | CN | disclosed |
| CN-114685519-A | Pyrano-carbazole alkaloid derivative and application thereof in treating Alzheimer's disease | 中国医学科学院药物研究所 | 2022-07-01 | — | — | CN | disclosed |