Koenimbine

Koenimbine

SCHEMBL29581663

COc1ccc2[nH]c3c4c(c(C)cc3c2c1)OC(C)(C)C=C4

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.69
▸ POLB P06746 4/20 0.69
▸ RAB9A P51151 3/20 0.69
▸ XBP1 P17861 2/20 0.69
▸ NPC1 O15118 1/20 0.69
▸ KMT2A Q03164 6/20 0.63
▸ KDM4E B2RXH2 6/20 0.63
▸ MEN1 O00255 5/20 0.63
▸ HSD17B10 Q99714 4/20 0.63
▸ ALDH1A1 P00352 3/20 0.63
▸ TSHR P16473 2/20 0.63
▸ HPGD P15428 2/20 0.63
▸ LMNA P02545 1/20 0.63
▸ CYP2C9 P11712 1/20 0.63
▸ CYP2C19 P33261 1/20 0.63
▸ HTT P42858 1/20 0.63
▸ GFER P55789 1/20 0.46
▸ BCHE P06276 2/20 0.45
▸ ACHE P22303 2/20 0.45
▸ PNLIP P16233 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30929792 0.91 MAPT (0.69) MAPTPOLBRAB9AXBP1NPC1
Claulansine F SCHEMBL29684000 0.84 ALDH1A1 (0.61) MAPTPOLBRAB9AXBP1NPC1
SCHEMBL29502491 0.83 MAPT (0.72) MAPTPOLBRAB9AXBP1NPC1
SCHEMBL30929796 0.83 MAPT (0.65) MAPTPOLBRAB9AXBP1NPC1
SCHEMBL31324206 0.82 MAPT (0.57) MAPTPOLBRAB9AXBP1NPC1
Grinimibine SCHEMBL4132680 0.82 MAPT (1.00) MAPTPOLBRAB9AXBP1NPC1
SCHEMBL28829841 0.80 KDM4E (0.55) MAPTPOLBRAB9AXBP1NPC1
SCHEMBL31324179 0.80 MAPT (0.60) MAPTPOLBRAB9AXBP1NPC1
Haplamine SCHEMBL257952 0.77 ALDH1A1 (1.00) MAPTPOLBRAB9AXBP1NPC1
Haplamine SCHEMBL30203195 0.77 ALDH1A1 (1.00) MAPTPOLBRAB9AXBP1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4647073-A1 MURRAYA KOENIGII IN THE TREATMENT OF UPPER RESPIRATORY TRACT INFECTIONS Nutraceutical Technology Pharma Biotech S.r.l. (IT) 2025-11-12 — — EP claimed
US-20220143124-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION LAILA NUTRACEUTICALS (IN) 2022-05-12 — — US claimed
CN-122094681-A Carbazole compounds and therapeutic use thereof in the treatment of respiratory infections — 2026-05-26 — — CN disclosed
EP-4743082-A1 CARBAZOLE COMPOUNDS AND THEIR USE IN THERAPY, IN THE TREATMENT OF A RESPIRATORY INFECTION UCL Business Ltd (GB) 2026-05-20 — — EP disclosed
EP-4647073-A1 MURRAYA KOENIGII IN THE TREATMENT OF UPPER RESPIRATORY TRACT INFECTIONS Nutraceutical Technology Pharma Biotech S.r.l. (IT) 2025-11-12 — — EP disclosed
WO-2025012634-A1 CARBAZOLE COMPOUNDS AND THEIR USE IN THERAPY, IN THE TREATMENT OF A RESPIRATORY INFECTION UCL BUSINESS LTD (GB) 2025-01-16 — — WO disclosed
CN-118141926-A Application of plant carbazole alkaloid in preparation of iron death inhibitor 北京大学 2024-06-07 — — CN disclosed
US-20230248737-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS OR SYMPTOMS THEREOF PSYRX LTD. (IL) 2023-08-10 — — US disclosed
EP-4175643-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS OR SYMPTOMS THEREOF Psyrx Ltd. (IL) 2023-05-10 — — EP disclosed
US-20220347185-A1 IBOGAINE FORMULATIONS CAAMTECH INC (US) 2022-11-03 — — US disclosed
US-20220143124-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION LAILA NUTRACEUTICALS (IN) 2022-05-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220347185-A1 IBOGAINE FORMULATIONS OPRK1, OPRL1, OPRD1 MAPT 1729/4885POLB 2600/4885RAB9A 456/4885
US-20220143124-A1 SYNERGISTIC HERBAL COMPOSITIONS FOR PREVENTION, TREATMENT OR CONTROL OF PAIN AND/OR CARTILAGE REGENERATION TNF, COL2A1, ALPI MAPT 3513/4885POLB 1575/4885RAB9A 1526/4885
US-20230248737-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS OR SYMPTOMS THEREOF GRIN2C, HTR5A, HTR2A MAPT 303/4885POLB 4467/4885RAB9A 720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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