Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.54 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28365128 | 0.85 | SIGMAR1 (0.60) | SIGMAR1ATMALDH1A1CXCR3CYP2A13 | |
| SCHEMBL28829907 | 0.84 | ACHE (0.65) | ATMALDH1A1CYP2A13BCHEACHE | |
| SCHEMBL25807943 | 0.83 | BCHE (0.65) | SIGMAR1ALDH1A1CXCR3BCHEACHE | |
| SCHEMBL28829847 | 0.82 | CXCR4 (0.60) | SIGMAR1ATMALDH1A1CYP2A13BCHE | |
| SCHEMBL21101178 | 0.81 | ATM (0.62) | SIGMAR1ATMALDH1A1CXCR3CYP2A13 | |
| Hydrochloric Acid SCHEMBL6647192 | 0.81 | SIGMAR1 (0.56) | SIGMAR1BCHEACHEBACE1POLB | |
| SCHEMBL16888834 | 0.80 | ATM (0.68) | SIGMAR1ATMALDH1A1CXCR3CYP2A13 | |
| SCHEMBL12013928 | 0.80 | ACHE (0.68) | SIGMAR1ATMALDH1A1CXCR3CYP2A13 | |
| SCHEMBL31448683 | 0.79 | CYP2A13 (0.69) | SIGMAR1ATMALDH1A1CXCR3CYP2A13 | |
| SCHEMBL2498286 | 0.78 | ACHE (0.73) | SIGMAR1BCHEACHEBACE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685519-B | Pyranocarbazole alkaloid derivatives and application thereof in treating Alzheimer's disease | 中国医学科学院药物研究所 | 2023-09-26 | — | — | CN | disclosed |
| CN-114685519-A | Pyrano-carbazole alkaloid derivative and application thereof in treating Alzheimer's disease | 中国医学科学院药物研究所 | 2022-07-01 | — | — | CN | disclosed |