Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 7/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28830325 | 0.83 | RAF1 (0.38) | CYP1A2CYP2D6MAPTPOLBRAF1 | |
| SCHEMBL28830297 | 0.83 | CYP1A2 (0.43) | CYP1A2CYP2D6MAPTPOLBLMNA | |
| SCHEMBL29762501 | 0.79 | GAA (0.41) | CYP1A2CYP2D6MAPTRAF1BRAF | |
| SCHEMBL23275378 | 0.79 | GAA (0.41) | CYP1A2CYP2D6MAPTRAF1BRAF | |
| SCHEMBL23299990 | 0.79 | GAA (0.41) | CYP1A2CYP2D6MAPTRAF1BRAF | |
| SCHEMBL8787610 | 0.77 | LMNA (0.36) | LMNAMCHR1 | |
| SCHEMBL23274606 | 0.76 | RAF1 (0.46) | CYP1A2CYP2D6MAPTPOLBRAF1 | |
| SCHEMBL29762401 | 0.76 | RAF1 (0.46) | CYP1A2CYP2D6MAPTPOLBRAF1 | |
| SCHEMBL23275320 | 0.75 | MAPT (0.40) | CYP1A2CYP2D6MAPTPOLBRAF1 | |
| SCHEMBL23275324 | 0.75 | MAPT (0.40) | CYP1A2CYP2D6MAPTPOLBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |