Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27635132 | 0.86 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28076478 | 0.85 | F9 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28076445 | 0.85 | ALDH1A1 (0.40) | LMNAMAPK1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL27770762 | 0.84 | MAPT (0.46) | MAPTLMNASMN1; SMN2SCN4ANPSR1 | |
| SCHEMBL28041869 | 0.81 | ALDH1A1 (0.43) | MAPTLMNATSHRSLC6A2SLC6A4 | |
| SCHEMBL28094567 | 0.81 | DPP4 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28136985 | 0.80 | SLC6A2 (0.41) | TSHRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL10216868 | 0.79 | CYP1A2 (0.50) | SMN1; SMN2GBA1SCN4ANPSR1 | |
| SCHEMBL19265306 | 0.79 | CYP1A2 (0.50) | SMN1; SMN2GBA1SCN4ANPSR1 | |
| Hydrochloric Acid SCHEMBL3446837 | 0.78 | CYP1A2 (0.49) | SMN1; SMN2GBA1SCN4ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658646-B | Aminoheteroaryl benzamide as kinase inhibitor | 诺华股份有限公司 | 2018-11-27 | — | — | CN | disclosed |
| CN-105658646-A | Aminoheteroaryl benzamides as kinase inhibitors | 诺华股份有限公司 | 2016-06-08 | — | — | CN | disclosed |