Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25245395 | 0.83 | IRAK4 (0.53) | L3MBTL1KMT2AHTTPOLBMEN1 | |
| SCHEMBL8749509 | 0.80 | KMT2A (0.53) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL30550438 | 0.80 | KMT2A (0.53) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL3645158 | 0.80 | KMT2A (0.53) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL12665837 | 0.80 | KMT2A (0.53) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL18304343 | 0.79 | PTGS2 (0.47) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL16796804 | 0.79 | L3MBTL1 (0.40) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL9537251 | 0.77 | KMT2A (0.42) | L3MBTL1KMT2ASMN1; SMN2HTTPOLB | |
| SCHEMBL24044801 | 0.77 | MEN1 (0.48) | KMT2AMEN1LMNA | |
| SCHEMBL909291 | 0.76 | KMT2A (0.44) | L3MBTL1KMT2ASMN1; SMN2HTTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814048-B | Fused tricyclic benzimidizole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105814048-A | Fused tricyclic imidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |