Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28077706 | 0.96 | MCL1 (0.50) | MCL1TDP1L3MBTL1LMNACES1 | |
| SCHEMBL16050429 | 0.79 | TSHR (0.60) | L3MBTL1NPC1TSHRMAPTKMT2A | |
| SCHEMBL28077720 | 0.78 | TSHR (0.57) | LMNATSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7543000 | 0.78 | LMNA (0.43) | TDP1L3MBTL1LMNACES1CES2 | |
| SCHEMBL7493232 | 0.78 | LMNA (0.43) | TDP1L3MBTL1LMNACES1CES2 | |
| SCHEMBL8393368 | 0.78 | TDP1 (0.42) | MCL1TDP1L3MBTL1LMNACES1 | |
| SCHEMBL28077872 | 0.76 | TSHR (0.64) | L3MBTL1LMNANPC1TSHRMAPT | |
| SCHEMBL29770503 | 0.76 | NPC1 (0.46) | MCL1TDP1L3MBTL1LMNACES1 | |
| SCHEMBL27784456 | 0.75 | MCL1 (0.41) | MCL1TDP1L3MBTL1LMNACES1 | |
| SCHEMBL27759419 | 0.75 | KMT2A (0.47) | MCL1L3MBTL1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105980386-A | Pyrazolo compounds and uses thereof | 基因泰克公司 | 2016-09-28 | — | — | CN | disclosed |