SCHEMBL28077720

SCHEMBL28077720

COC(=O)C(C(=O)c1ccccc1)C1CCCC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.57
KMT2A Q03164 4/20 0.56
ALDH1A1 P00352 3/20 0.52
NPSR1 Q6W5P4 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.50
THRB P10828 1/20 0.45
MEN1 O00255 2/20 0.45
MAPK1 P28482 1/20 0.45
SLC6A3 Q01959 5/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
SCN1A P35498 1/20 0.45
SCN2A Q99250 1/20 0.45
SCN3A Q9NY46 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
DHFR P00374 1/20 0.45
ATM Q13315 1/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8375718 0.94 TSHR (0.49) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL28077872 0.85 TSHR (0.64) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL14014030 0.84 SMN1; SMN2 (0.50) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL14257280 0.84 SMN1; SMN2 (0.50) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL4710089 0.83 SMN1; SMN2 (0.53) KMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL16050429 0.82 TSHR (0.60) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL28077706 0.82 MCL1 (0.50) TSHRKMT2AMEN1LMNACYP1A2
SCHEMBL28833134 0.78 MCL1 (0.46) TSHRKMT2AALDH1A1SMN1; SMN2MEN1
SCHEMBL14038771 0.77 ALDH1A1 (0.50) KMT2AALDH1A1NPSR1SMN1; SMN2MEN1
SCHEMBL4491334 0.77 THRB (0.61) TSHRKMT2AALDH1A1NPSR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105753682-A Preparation method of cyclopentyl phenyl ketone 中国科学院成都有机化学有限公司 2016-07-13 CN claimed
CN-105753682-B A kind of preparation method of phenylcyclopentyl ketone 中国科学院成都有机化学有限公司 2018-01-09 CN disclosed
CN-105753682-A Preparation method of cyclopentyl phenyl ketone 中国科学院成都有机化学有限公司 2016-07-13 CN disclosed
CN-105753682-A Preparation method of cyclopentyl phenyl ketone 中国科学院成都有机化学有限公司 2016-07-13 CN disclosed