SCHEMBL28833757

SCHEMBL28833757

COC(=O)NCc1cc(C(C)OCc2cccc(C)c2)ccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
HSP90AA1 P07900 1/20 0.39
FFAR1 O14842 1/20 0.39
CYP2D6 P10635 2/20 0.38
CYP2C19 P33261 1/20 0.38
PPARG P37231 1/20 0.37
NPC1 O15118 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28618252 0.85 MEN1 (0.43) MEN1KMT2AHSP90AA1FFAR1PPARG
SCHEMBL28833758 0.84 MEN1 (0.44) MEN1KMT2AHSP90AA1FFAR1NPC1
SCHEMBL3236733 0.75 NPC1 (0.49) TSHRMEN1KMT2AHSP90AA1PPARG
SCHEMBL18243 0.75 NPC1 (0.49) TSHRMEN1KMT2AHSP90AA1PPARG
SCHEMBL17845833 0.74 TSHR (0.42) TSHRMEN1KMT2AHSP90AA1PPARG
SCHEMBL8257957 0.73 TSHR (0.58) TSHRCYP2D6CYP2C19NPC1SMN1; SMN2
SCHEMBL4563137 0.73 PPARG (0.39) TSHRMEN1KMT2AHSP90AA1PPARG
SCHEMBL26317 0.67 NPC1 (0.53) MEN1KMT2AHSP90AA1PPARGNPC1
SCHEMBL26318 0.67 NPC1 (0.53) MEN1KMT2AHSP90AA1PPARGNPC1
SCHEMBL4623701 0.67 TSHR (0.62) TSHRMEN1KMT2ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114867350-A Low volatility polyamine salts of anionic pesticides 巴斯夫公司 2022-08-05 CN disclosed
CN-109970760-B ACC inhibitors and uses thereof 吉利德阿波罗公司 2022-04-26 CN disclosed