SCHEMBL3236733

SCHEMBL3236733

COC(=O)NCc1cc(/C(C)=N/OCc2cccc(C)c2)ccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
PPARG P37231 8/20 0.43
PPARA Q07869 6/20 0.43
MAOB P27338 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
HSP90AA1 P07900 1/20 0.40
TSHR P16473 1/20 0.40
S1PR1 P21453 3/20 0.39
S1PR3 Q99500 1/20 0.39
CTSB P07858 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18243 1.00 NPC1 (0.49) NPC1RAB9APPARGPPARAMAOB
SCHEMBL26318 0.93 NPC1 (0.53) NPC1RAB9APPARGPPARAMAOB
SCHEMBL26317 0.93 NPC1 (0.53) NPC1RAB9APPARGPPARAMAOB
SCHEMBL4667807 0.88 NPC1 (0.48) NPC1RAB9APPARGPPARAMAOB
SCHEMBL4563137 0.87 PPARG (0.39) NPC1RAB9APPARGMAOBMEN1
SCHEMBL31532164 0.85 NPC1 (0.51) NPC1RAB9APPARGPPARAMAOB
SCHEMBL4624388 0.83 S1PR1 (0.50) NPC1RAB9APPARGPPARAMEN1
SCHEMBL4624392 0.83 S1PR1 (0.50) NPC1RAB9APPARGPPARAMEN1
SCHEMBL29060560 0.83 LMNA (0.39) NPC1RAB9APPARGMEN1KMT2A
SCHEMBL25344075 0.82 NPC1 (0.50) NPC1RAB9APPARGPPARAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100292237-A1 Method for Combating Phytopathogenic Fungi BASF SE (DE) 2010-11-18 US claimed
US-20090233916-A1 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS BASF SE (DE) 2009-09-17 US claimed
US-20090011935-A1 Method of Inducing Tolerance of Plants Against Bacterioses BASF SE (DE) 2009-01-08 US claimed
EP-2001294-A2 METHOD FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2008-12-17 EP claimed
EP-1996018-A2 METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES BASF SE (DE) 2008-12-03 EP claimed
EP-1993358-A2 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS BASF SE (DE) 2008-11-26 EP claimed
WO-2007110354-A2 METHOD FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2007-10-04 WO claimed
WO-2007104669-A2 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS BASF SE (DE) 2007-09-20 WO claimed
WO-2007104658-A2 METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES BASF SE (DE) 2007-09-20 WO claimed
US-20170359965-A1 POLYLACTIC ACID COMPOSITIONS WITH ACCELERATED DEGRADATION RATE AND INCREASED HEAT STABILITY DU PONT (US) 2017-12-21 US disclosed
WO-2016099916-A1 POLYLACTIC ACID COMPOSITIONS WITH ACCELERATED DEGRADATION RATE AND INCREASED HEAT STABILITY E. I. DU PONT DE NEMOURS AND COMPANY (US) 2016-06-23 WO disclosed
US-20160095321-A1 SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS AGRAQUEST, INC. 2016-04-07 US disclosed
US-9049814-B2 Coated seeds and methods of making coated seeds VAMTECH, LLC (US) 2015-06-09 US disclosed
US-20130180173-A1 PLANT ARTIFICIAL SEEDS HAVING MULTILAYERS AND METHODS FOR THE PRODUCTION THEREOF E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-18 US disclosed
WO-2006108834-A1 USE OF BASIC AMINO ACIDS IN BIOCIDE FORMULATIONS CONTAINING COPPER BASF AKTIENGESELLSCHAFT (DE) 2006-10-19 WO disclosed
WO-2006108835-A2 USE OF POLYLYSINE IN BIOCIDE FORMULATIONS CONTAINING COPPER BASF AKTIENGESELLSCHAFT (DE) 2006-10-19 WO disclosed
WO-2006000383-A1 AQUEOUS DISPERSIONS COMPRISING ACTIVE SUBSTANCES THAT ARE DIFFICULT OR IMPOSSIBLE TO DISSOLVE IN WATER, AND DRY POWDERS WHICH ARE PRODUCED THEREFROM AND CONTAIN AT LEAST ONE POLYMER CONTAINING POLYETHER GROUPS AS A PROTECTIVE COLLOID BASF AKTIENGESELLSCHAFT (DE) 2006-01-05 WO disclosed
WO-2006000592-A1 USE OF ETHER GROUP-CONTAINING POLYMERS AS SOLUBILIZERS BASF AKTIENGESELLSCHAFT (DE) 2006-01-05 WO disclosed
WO-2005077170-A1 FORMULATION FOR SEED TREATMENT COMPRISING POLYMERIC STICKERS BASF AKTIENGESELLSCHAFT (DE) 2005-08-25 WO disclosed
WO-2005077169-A1 FORMULATION FOR SEED TREATMENT BASF AKTIENGESELLSCHAFT (DE) 2005-08-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090011935-A1 Method of Inducing Tolerance of Plants Against Bacterioses BROX, CAT, SLC11A2 NPC1 1971/4885RAB9A 3551/4885PPARG 426/4885
US-20100292237-A1 Method for Combating Phytopathogenic Fungi CYC1, UQCRC1, MT-CO2 NPC1 884/4885RAB9A 3649/4885PPARG 3409/4885
US-20090233916-A1 METHOD OF INDUCING VIRUS TOLERANCE OF PLANTS EIF2AK2, CAT, SLC11A2 NPC1 2103/4885RAB9A 3589/4885PPARG 1025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.