Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220074 | 0.95 | MAPT (0.47) | MAPTEPHX2CHRNA7GPR3KIF11 | |
| SCHEMBL7469958 | 0.93 | MAPT (0.45) | MAPTEPHX2CHRNA7GPR3KIF11 | |
| SCHEMBL30056405 | 0.93 | MAPT (0.45) | MAPTEPHX2CHRNA7GPR3KIF11 | |
| Bromide SCHEMBL28835122 | 0.91 | MAPT (0.44) | MAPTEPHX2CHRNA7GPR3KIF11 | |
| SCHEMBL4150750 | 0.88 | KIF11 (0.49) | MAPTEPHX2KIF11NISCHCA9 | |
| SCHEMBL1393658 | 0.88 | MAPT (0.52) | MAPTEPHX2CHRNA7GPR3KIF11 | |
| SCHEMBL17281262 | 0.83 | GLB1 (0.47) | MAPTEPHX2CHRNA7GPR3PDE2A | |
| SCHEMBL4617903 | 0.83 | KIF11 (0.45) | MAPTEPHX2CHRNA7KIF11WDR5 | |
| SCHEMBL15207305 | 0.83 | CHRNA7 (0.53) | MAPTEPHX2CHRNA7GPR3WDR5 | |
| SCHEMBL254957 | 0.82 | MAPT (0.56) | MAPTEPHX2GPR3KIF11L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339123-B | Indeno fused ring compounds having photochromic properties | TRANSITIONS OPTICAL, INC. (US) | 2016-11-30 | — | — | CN | disclosed |