SCHEMBL2883739

SCHEMBL2883739

Fc1ccc(P(Cl)Cl)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
CES2 O00748 2/20 0.38
CES1 P23141 2/20 0.38
CA3 P07451 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
NFE2L2 Q16236 3/20 0.34
IDO1 P14902 2/20 0.34
AGXT P21549 2/20 0.34
CYP1A2 P05177 1/20 0.32
CYP2A6 P11509 1/20 0.32
KCNN4 O15554 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29349450 1.00 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6
SCHEMBL8019931 0.85 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6
SCHEMBL29350948 0.85 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6
SCHEMBL19921795 0.79 ALDH1A1 (0.46) ALDH1A1CES2CES1CA3CA6
SCHEMBL29716617 0.79 ALDH1A1 (0.46) ALDH1A1CES2CES1CA3CA6
SCHEMBL28952271 0.76 DGAT1 (0.39) ALDH1A1CYP2A6
SCHEMBL29350446 0.76 HTT (0.36) ALDH1A1CES2CES1CA3CA6
SCHEMBL6793057 0.75 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6
SCHEMBL19968270 0.75 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6
SCHEMBL29350421 0.75 ALDH1A1 (0.42) ALDH1A1CES2CES1CA3CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1354886-B1 Process for the preparation of tertiary phosphines SALTIGO GMBH (DE) 2009-08-26 EP claimed
US-7230136-B2 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2007-06-12 US claimed
US-20030229240-A1 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2003-12-11 US claimed
EP-1354886-A1 Process for the preparation of tertiary phosphines Bayer Aktiengesellschaft (DE) 2003-10-22 EP claimed
CN-107592863-A Chromium complex and olefin oligomerization catalyst therefrom with the part containing phosphorus ring 陶氏环球技术有限责任公司 2018-01-16 CN disclosed
CN-107567355-A The part containing phosphorus ring and olefin oligomerization catalyst therefrom for chromium complex 陶氏环球技术有限责任公司 2018-01-09 CN disclosed
CN-107548385-A Olefin oligomerization process using catalyst comprising chromium complex with phosphacycle-containing ligand 陶氏环球技术有限责任公司 2018-01-05 CN disclosed
US-7847126-B2 prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example LANXESS DEUTSCHLAND GMBH (DE) 2010-12-07 US disclosed
EP-1354886-B1 Process for the preparation of tertiary phosphines SALTIGO GMBH (DE) 2009-08-26 EP disclosed
US-20070299273-A1 prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example LANXESS DEUTSCHLAND GMBH (DE) 2007-12-27 US disclosed
US-7230136-B2 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2007-06-12 US disclosed
US-20030229240-A1 Reacting phosphorus halide with organomagnesium compound in presence of copper compound LANXESS DEUTSCHLAND GMBH (DE) 2003-12-11 US disclosed
EP-1354886-A1 Process for the preparation of tertiary phosphines Bayer Aktiengesellschaft (DE) 2003-10-22 EP disclosed