Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9607437 | 0.88 | PIP4K2A (0.57) | PIP4K2ASCN10APRMT6CYP11B1CYP11B2 | |
| SCHEMBL28104718 | 0.86 | PIP4K2A (0.46) | PIP4K2ASCN10APRMT6CYP11B1CYP11B2 | |
| SCHEMBL1230329 | 0.79 | PIP4K2A (0.51) | PIP4K2ASCN10APRMT6CYP11B1CYP11B2 | |
| SCHEMBL29066290 | 0.77 | PIP4K2B (0.54) | PIP4K2ACYP11B1CYP11B2PIP4K2BCA12 | |
| SCHEMBL2318682 | 0.77 | MAP4K4 (0.55) | CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL17103331 | 0.76 | ALDH1A1 (0.48) | DRD1KIF11 | |
| SCHEMBL27995027 | 0.75 | CYP11B2 (0.55) | SCN10ACYP11B1CYP11B2ABL1MAP4K4 | |
| SCHEMBL1582492 | 0.75 | PIP4K2B (0.51) | SCN10ACYP11B1CYP11B2PIP4K2BPTGS2 | |
| SCHEMBL29598147 | 0.75 | PIP4K2B (0.51) | SCN10ACYP11B1CYP11B2PIP4K2BPTGS2 | |
| SCHEMBL31180051 | 0.74 | PTGS2 (0.38) | PIP4K2APIP4K2BPTGS2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104379574-B | For suppressing the heterocyclic carbamate derivatives of the activity of ABL1, ABL2 and BCR ABL1 | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |