Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28162632 | 0.80 | HTR2A (0.42) | MTNR1AHTR2CHTR2BADRA2BADRA2C | |
| SCHEMBL5326420 | 0.78 | HTR2C (0.40) | MTNR1AMEN1USP2ALDH1A1CDK4 | |
| SCHEMBL811848 | 0.78 | POLB (0.51) | MTNR1AMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL15222054 | 0.78 | POLB (0.51) | MTNR1AMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL9230128 | 0.78 | POLB (0.51) | MTNR1AMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL29659945 | 0.78 | POLB (0.51) | MTNR1AMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL23505301 | 0.77 | MTNR1A (0.49) | MTNR1AMEN1USP2ALDH1A1CDK4 | |
| SCHEMBL30018725 | 0.77 | MTNR1A (0.46) | MTNR1AMEN1USP2ALDH1A1CDK4 | |
| SCHEMBL11262644 | 0.77 | MTNR1A (0.46) | MTNR1AMEN1USP2ALDH1A1CDK4 | |
| SCHEMBL28136142 | 0.77 | MTNR1A (0.46) | MTNR1AMEN1USP2ALDH1A1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106660998-A | Pyrazolyl-3, 4-dihydroquinolin-2-one aldosterone synthase inhibitors | 豪夫迈·罗氏有限公司 | 2017-05-10 | — | — | CN | disclosed |