Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ME2 | P23368 | 1/20 | 0.33 |
| ▸ | ME1 | P48163 | 1/20 | 0.33 |
| ▸ | ME3 | Q16798 | 1/20 | 0.33 |
| ▸ | BMI1 | P35226 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27898833 | 0.80 | FPR2 (0.41) | ME2ME1ME3CACNA1G | |
| SCHEMBL28148590 | 0.77 | GOT1 (0.39) | CACNA1G | |
| SCHEMBL17700425 | 0.77 | HRH4 (0.38) | CYP11B1CYP11B2IL1BTNF | |
| SCHEMBL2562929 | 0.77 | MEN1 (0.38) | KMT2AMEN1IL1BTNFCACNA1G | |
| SCHEMBL17240868 | 0.75 | IL1B (0.36) | LMNAKMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14734750 | 0.73 | MEN1 (0.32) | KMT2AHTTMEN1SMN1; SMN2IL1B | |
| SCHEMBL21170499 | 0.73 | KDM4E (0.40) | LMNAKMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21170299 | 0.72 | NPC1 (0.47) | LMNAKMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17240865 | 0.71 | IL1B (0.33) | IL1BTNFCACNA1G | |
| SCHEMBL2561843 | 0.71 | MAPT (0.43) | KMT2AHTTMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107266419-A | Specific amino pyridazine class, thing in combination, and its application method | 赛特凯恩蒂克公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-103002897-B | Certain amino-pyridazines, compositions thereof, and methods of use thereof | 赛特凯恩蒂克公司 | 2017-06-09 | — | — | CN | disclosed |