Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.52 |
| ▸ | RAB9A | P51151 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 13/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154610 | 0.88 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL16217116 | 0.85 | MEN1 (0.58) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28154695 | 0.82 | RAB9A (0.46) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL24617416 | 0.81 | HPGDS (0.53) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL29674695 | 0.81 | HPGDS (0.53) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28155545 | 0.81 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL28154660 | 0.81 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28845873 | 0.80 | RAB9A (0.44) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28091731 | 0.80 | RAB9A (0.51) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28154584 | 0.80 | MEN1 (0.55) | NPC1RAB9AMEN1KMT2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |