SCHEMBL2884641

SCHEMBL2884641

O=C1c2ccccc2C(=O)N1c1cccc(N2C(=O)c3ccc(Cl)cc3C2=O)c1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.62
KMT2A Q03164 3/20 0.62
KDM4E B2RXH2 1/20 0.56
ALDH1A1 P00352 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
CASP6 P55212 1/20 0.55
ESR1 P03372 2/20 0.54
NR1H3 Q13133 1/20 0.53
PGR P06401 1/20 0.52
SCN2A Q99250 1/20 0.51
POLB P06746 1/20 0.51
MAPK1 P28482 1/20 0.51
S100A4 P26447 1/20 0.50
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
MGLL Q99685 1/20 0.49
GRM5 P41594 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL726842 0.96 KDM4E (0.59) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL9358156 0.93 ALDH1A1 (0.64) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL1500602 0.89 MEN1 (0.67) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL2553055 0.89 KDM4E (0.68) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL3846075 0.88 ALDH1A1 (0.49) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL9453218 0.85 MEN1 (0.57) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL9453237 0.85 KDM4E (0.52) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL9453320 0.85 KDM4E (0.52) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL19936849 0.85 MAPK1 (0.63) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL725608 0.85 NR1H3 (0.67) MEN1KMT2AALDH1A1ESR1NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2009521548-A 2009-06-04 JP claimed
EP-1966320-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES General Electric Company (US) 2008-09-10 EP claimed
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP claimed
EP-1963433-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS General Electric Company (US) 2008-09-03 EP claimed
EP-1960470-A2 FOOD SERVICE ARTICLES OF MANUFACTURE COMPRISING HIGH TEMPERATURE POLYMERS General Electric Company (US) 2008-08-27 EP claimed
WO-2008091253-A1 HIGH HEAT ELECTRICAL CONNECTORS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-31 WO claimed
WO-2008088336-A1 COATED ARTICLES OF MANUFACTURE MADE OF HIGH Tg POLYMER BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-24 WO claimed
WO-2007078737-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007078788-A2 FOOD SERVICE ARTICLES OF MANUFACTURE COMPRISING HIGH TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007078713-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007075365-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS GENERAL ELECTRIC COMPANY (US) 2007-07-05 WO claimed
US-20070149629-A1 Expanded and expandable high glass transition temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-28 US claimed
US-20070142569-A1 Food service articles of manufacture comprising high temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-21 US claimed
US-20070065615-A1 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
US-20070066740-A1 Annular or tubular shaped articles of novel polymer blends CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
US-20070066741-A1 High glass transition temperature thermoplastic articles CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
US-20070066739-A1 Coated articles of manufacture made of high Tg polymer blends GENERAL ELECTRIC COMPANY 2007-03-22 US claimed
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP claimed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed