Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28847140 | 0.79 | MAPT (0.64) | LMNAALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL29950353 | 0.73 | SGMS2 (0.58) | LMNAALDH1A1MAPTMAPK1SGMS2 | |
| SCHEMBL28847163 | 0.73 | SGMS2 (0.58) | LMNAALDH1A1MAPTMAPK1SGMS2 | |
| SCHEMBL19133748 | 0.73 | SGMS2 (0.58) | ALDH1A1MAPK1SGMS2 | |
| SCHEMBL19133755 | 0.73 | SGMS2 (0.58) | ALDH1A1MAPK1SGMS2 | |
| SCHEMBL11194354 | 0.69 | MAPT (0.74) | LMNAALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL28847217 | 0.69 | MAPT (0.46) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL21118532 | 0.68 | MAPT (0.58) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4651272 | 0.68 | MAPT (1.00) | ALDH1A1MAPTMAPK1KDM4EMEN1 | |
| SCHEMBL29989633 | 0.68 | MAPT (1.00) | ALDH1A1MAPTMAPK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | disclosed |