Benzene

Benzene

SCHEMBL28847299

COC(=O)CCC(NC(=O)OC(C)(C)C)C(=O)O.c1ccccc1

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 9/20 0.51
PPARG P37231 8/20 0.51
ACE P12821 1/20 0.50
PPARD Q03181 2/20 0.49
CTSK P43235 5/20 0.45
CTSS P25774 5/20 0.45
IDO1 P14902 1/20 0.44
ALDH1A1 P00352 1/20 0.44
TSHR P16473 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HTT P42858 1/20 0.44
CTSL P07711 1/20 0.43
CTSB P07858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2323692 0.97 PPARA (0.47) PPARAPPARGACEPPARDCTSK
SCHEMBL384624 0.97 PPARA (0.47) PPARAPPARGACEPPARDCTSK
SCHEMBL6337223 0.97 PPARA (0.47) PPARAPPARGACEPPARDCTSK
SCHEMBL2564729 0.89 PPARA (0.48) PPARAPPARGACEPPARDCTSK
SCHEMBL617475 0.89 PPARA (0.48) PPARAPPARGACEPPARDCTSK
SCHEMBL617476 0.89 PPARA (0.48) PPARAPPARGACEPPARDCTSK
SCHEMBL2726974 0.88 CTSK (0.51) PPARAPPARGACECTSKCTSS
SCHEMBL211797 0.88 CTSK (0.51) PPARAPPARGACECTSKCTSS
SCHEMBL211798 0.88 CTSK (0.51) PPARAPPARGACECTSKCTSS
SCHEMBL22283971 0.88 CTSK (0.46) PPARAPPARGACECTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107253968-A Pass through the γ of witig reaction, the general and stereoselectivesynthesis of δ unsaturation amino acid 国家科学研究中心 2017-10-17 CN disclosed
CN-103889994-B Universal and stereospecific synthesis of gamma-unsaturated amino acids by Wittig reaction 国家科学研究中心 2017-07-11 CN disclosed