Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 6/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.31 |
| ▸ | TEC | P42680 | 1/20 | 0.30 |
| ▸ | TXK | P42681 | 1/20 | 0.30 |
| ▸ | BMX | P51813 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28164526 | 0.80 | GAA (0.35) | MEN1POLBGAAKMT2ANPC1 | |
| SCHEMBL28164553 | 0.80 | ALOX5 (0.32) | ESR2NPC1RAB9ABTK | |
| SCHEMBL28166035 | 0.73 | CDK4 (0.43) | MEN1MAPTKMT2APABPC1 | |
| SCHEMBL28165056 | 0.73 | BTK (0.46) | BTKPABPC1TECTXKBMX | |
| SCHEMBL28165155 | 0.73 | BTK (0.46) | BTK | |
| SCHEMBL28164562 | 0.71 | AHR (0.53) | PKMKDM4EMAPTNPC1BTK | |
| SCHEMBL28335791 | 0.71 | BRD4 (0.43) | BTK | |
| SCHEMBL28335872 | 0.71 | BTK (0.37) | BTK | |
| SCHEMBL28165044 | 0.71 | BRD4 (0.43) | BTK | |
| SCHEMBL28164519 | 0.69 | MEN1 (0.36) | PKMESR2KDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |