SCHEMBL28848599

SCHEMBL28848599

CCn1ccc(C=O)n1.O=Cc1ccn[nH]1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
COMT P21964 1/20 0.38
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL478779 0.83
Propionaldehyde SCHEMBL28848688 0.78 ALDH1A1 (0.36) ALDH1A1
SCHEMBL28166966 0.76 HRH3 (0.39)
SCHEMBL193780 0.74
SCHEMBL29957432 0.70 ALDH1A1 (0.33) ALDH1A1
SCHEMBL28166788 0.69 L3MBTL1 (0.38) ALDH1A1
Formic Acid SCHEMBL30730045 0.69 HCAR2 (0.40)
SCHEMBL17687127 0.67
SCHEMBL4559047 0.66 NPC1 (0.36) ALDH1A1
SCHEMBL2185888 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105189504-B Fused tetracyclic bromodomain inhibitors 艾伯维公司 2017-07-18 CN disclosed