Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | CALCA | P06881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848976 | 0.80 | LMNA (0.42) | L3MBTL1 | |
| SCHEMBL30289501 | 0.77 | AAK1 (0.52) | AAK1PTPRC | |
| SCHEMBL24662352 | 0.76 | AAK1 (0.37) | AAK1ZAP70SYKCCNT1L3MBTL1 | |
| SCHEMBL20536454 | 0.76 | HSD17B2 (0.38) | AAK1CCNT1L3MBTL1PTPRC | |
| SCHEMBL24815322 | 0.74 | ABL1 (0.43) | AAK1PTPRC | |
| SCHEMBL24662900 | 0.73 | AAK1 (0.39) | AAK1CCNT1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL23810655 | 0.73 | NPC1 (0.38) | AAK1CCNT1L3MBTL1PTPRCCCNB2 | |
| SCHEMBL5549639 | 0.73 | PTPRC (0.42) | PTPRC | |
| SCHEMBL24662350 | 0.72 | TBK1 (0.38) | AAK1SYK | |
| SCHEMBL1884791 | 0.71 | CA12 (0.44) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-A | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |