Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18174193 | 0.81 | LMNA (0.51) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL28848962 | 0.80 | AAK1 (0.35) | L3MBTL1 | |
| SCHEMBL18172308 | 0.80 | GLA (0.41) | LMNAGLAMAPK1L3MBTL1MAPT | |
| SCHEMBL30288984 | 0.79 | LMNA (0.43) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL20535567 | 0.79 | LMNA (0.44) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL26830787 | 0.78 | MAPT (0.56) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL21501953 | 0.78 | LMNA (0.52) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL25139738 | 0.77 | ALDH1A1 (0.53) | LMNAL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL5550066 | 0.76 | KMT2A (0.50) | LMNAMAPK1L3MBTL1MAPTKMT2A | |
| SCHEMBL22164012 | 0.75 | MAPT (0.41) | LMNAMAPTKMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-A | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |