Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 8/20 | 0.66 |
| ▸ | GALR3 | O60755 | 2/20 | 0.63 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.62 |
| ▸ | TSHR | P16473 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.57 |
| ▸ | USP2 | O75604 | 7/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880436 | 0.87 | HTT (0.71) | LMNAHTTSMN1; SMN2MAPK1TSHR | |
| SCHEMBL2884882 | 0.84 | ALDH1A1 (0.58) | LMNAHTTSMN1; SMN2ERBB2EGFR | |
| SCHEMBL17845927 | 0.81 | LMNA (1.00) | LMNAHTTSMN1; SMN2EGFRGALR3 | |
| SCHEMBL2880273 | 0.80 | MAOB (0.61) | LMNAHTTSMN1; SMN2ERBB2EGFR | |
| SCHEMBL2880271 | 0.80 | MAOB (0.61) | LMNAHTTSMN1; SMN2ERBB2EGFR | |
| SCHEMBL1734678 | 0.80 | LMNA (0.72) | LMNAHTTSMN1; SMN2EGFRGALR3 | |
| SCHEMBL9921364 | 0.80 | LMNA (0.72) | LMNAHTTSMN1; SMN2EGFRGALR3 | |
| SCHEMBL9973593 | 0.80 | EGFR (0.65) | LMNAHTTERBB2EGFRMAPK1 | |
| SCHEMBL7612718 | 0.78 | EGFR (1.00) | LMNAHTTSMN1; SMN2EGFRGALR3 | |
| SCHEMBL29386010 | 0.78 | EGFR (1.00) | LMNAHTTSMN1; SMN2EGFRGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| CN-1681811-B | Azolidinone-vinyl fused-benzene derivatives | APPLIED RESEARCH SYSTEMS | 2010-05-26 | — | — | CN | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | disclosed |
| CN-1681811-A | Azolidinone-vinyl fused-benzene derivatives | APPLIED RESEARCH SYSTEMS (AN) | 2005-10-12 | — | — | CN | disclosed |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | ZAP70, BRCA1, ZYX | LMNA 3252/4885HTT 1649/4885SMN1; SMN2 2134/4885 |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | CATSPER1, PI4KB, MAN2B2 | LMNA 1094/4885HTT 3887/4885SMN1; SMN2 3624/4885 |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | BRCA1, ZAP70, F13B | LMNA 3373/4885HTT 1583/4885SMN1; SMN2 2104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.