Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536733 | 0.83 | RAPGEF4 (0.38) | RAPGEF4 | |
| SCHEMBL5362839 | 0.82 | RAPGEF4 (0.39) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL9329893 | 0.78 | RAPGEF4 (0.42) | RAPGEF4ALDH1A1FFAR4CA1CA2 | |
| SCHEMBL1043330 | 0.78 | RAPGEF4 (0.39) | RAPGEF4ALDH1A1LMNACYP1A2TSHR | |
| SCHEMBL11785341 | 0.75 | RAPGEF4 (0.43) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL301709 | 0.75 | RAPGEF4 (0.43) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| Silver SCHEMBL31010581 | 0.73 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL31325570 | 0.73 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| Iodide SCHEMBL9662368 | 0.73 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1KDM4ELMNAGAA | |
| Bromide SCHEMBL3679642 | 0.73 | RAPGEF4 (0.41) | RAPGEF4ALDH1A1KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103613618-B | A kind of [2.2] multiply biology and preparation method thereof and application to ring | JIANG University OF TECHNOLOGY (CN) | 2015-10-28 | — | — | CN | claimed |
| CN-103613618-A | [2.2] paracyclophane derivative as well as preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-03-05 | — | — | CN | claimed |
| EP-1354886-B1 | Process for the preparation of tertiary phosphines | SALTIGO GMBH (DE) | 2009-08-26 | — | — | EP | claimed |
| US-7230136-B2 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2007-06-12 | — | — | US | claimed |
| US-20030229240-A1 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2003-12-11 | — | — | US | claimed |
| EP-1354886-A1 | Process for the preparation of tertiary phosphines | Bayer Aktiengesellschaft (DE) | 2003-10-22 | — | — | EP | claimed |
| CN-103613618-B | A kind of [2.2] multiply biology and preparation method thereof and application to ring | JIANG University OF TECHNOLOGY (CN) | 2015-10-28 | — | — | CN | disclosed |
| CN-103613618-A | [2.2] paracyclophane derivative as well as preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-03-05 | — | — | CN | disclosed |
| US-7847126-B2 | prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example | LANXESS DEUTSCHLAND GMBH (DE) | 2010-12-07 | — | — | US | disclosed |
| EP-1354886-B1 | Process for the preparation of tertiary phosphines | SALTIGO GMBH (DE) | 2009-08-26 | — | — | EP | disclosed |
| US-20070299273-A1 | prepared by reacting phosphorus halide with organomagnesium compound in presence of copper compound; di(tert-butyl)phenylphosphonium tetrafluoroborate, for example | LANXESS DEUTSCHLAND GMBH (DE) | 2007-12-27 | — | — | US | disclosed |
| US-7250519-B2 | Method for the production of arylamines | MERCK PATENT GMBH (DE) | 2007-07-31 | — | — | US | disclosed |
| US-7230136-B2 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2007-06-12 | — | — | US | disclosed |
| US-20050054854-A1 | Method for the production of arylamines | MERCK PATENT GMBH (DE) | 2005-03-10 | — | — | US | disclosed |
| EP-1442007-A1 | METHOD FOR THE PRODUCTION OF ARYLAMINES | Covion Organic Semiconductors GmbH (DE) | 2004-08-04 | — | — | EP | disclosed |
| US-20030229240-A1 | Reacting phosphorus halide with organomagnesium compound in presence of copper compound | LANXESS DEUTSCHLAND GMBH (DE) | 2003-12-11 | — | — | US | disclosed |
| EP-1354886-A1 | Process for the preparation of tertiary phosphines | Bayer Aktiengesellschaft (DE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2003078478-A1 | CATALYSTS FOR OLEFIN POLYMERIZATION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-09-25 | — | — | WO | disclosed |
| WO-2003076450-A1 | CATALYSTS FOR OLEFIN POLYMERIZATION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003037844-A1 | METHOD FOR THE PRODUCTION OF ARYLAMINES | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054854-A1 | Method for the production of arylamines | DDT, PDS5A, KMO | RAPGEF4 3564/4885ALDH1A1 2177/4885KDM4E 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.