SCHEMBL28849409

SCHEMBL28849409

O=C(O)Cc1ccccc1-c1ccc2ccccc2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 2/20 0.51
PTGER4 P35408 2/20 0.51
PTGER3 P43115 2/20 0.51
PTGER2 P43116 2/20 0.51
PTGS2 P35354 1/20 0.51
CCNC P24863 1/20 0.51
CDK8 P49336 1/20 0.51
GSTP1 P09211 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
SLC6A2 P23975 1/20 0.49
SLC6A4 P31645 1/20 0.49
SLC6A3 Q01959 1/20 0.49
S1PR5 Q9H228 6/20 0.47
S1PR4 O95977 5/20 0.47
AKR1B1 P15121 1/20 0.47
ENPP2 Q13822 1/20 0.47
ACMSD Q8TDX5 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14873474 0.88 CCNC (0.52) CCNCCDK8GSTP1HDAC4HDAC2
SCHEMBL5048312 0.85 SLC6A2 (0.51) CCNCCDK8GSTP1HDAC4HDAC2
SCHEMBL5381541 0.81 S1PR5 (0.48) CCNCCDK8GSTP1HDAC4HDAC2
SCHEMBL5961842 0.80 PTGS1 (0.59) PTGER1PTGER4PTGER3PTGER2PTGS2
SCHEMBL538512 0.80 KMT2A (0.60) PTGER1PTGER4PTGER3PTGER2PTGS2
SCHEMBL477558 0.79 GSTP1 (0.52) CCNCCDK8GSTP1HDAC4HDAC2
SCHEMBL11018452 0.79 TRPA1 (0.58) CCNCCDK8GSTP1HDAC4HDAC2
SCHEMBL9890645 0.79 PTGS2 (0.53) PTGER1PTGER4PTGER3PTGER2PTGS2
SCHEMBL29459923 0.79 PTGS2 (0.53) PTGER1PTGER4PTGER3PTGER2PTGS2
Hydrochloric Acid SCHEMBL11895689 0.78 KMT2A (0.58) PTGER1PTGER4PTGER3PTGER2PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108905-A Method for generating (Z) -trifluoromethane enol ester by copper-catalyzed regioselective olefination and trifluoromethylation of carboxylic acid 湖南大学 2022-09-27 CN disclosed