SCHEMBL28849999

SCHEMBL28849999

CC1(C)C([SH](=O)=O)=Cc2ccccc21

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 4/20 0.38
PDK4 Q16654 3/20 0.38
PGR P06401 2/20 0.33
PDK1 Q15118 1/20 0.33
PDK3 Q15120 1/20 0.33
HCAR2 Q8TDS4 1/20 0.31
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2047468 0.70 PDK2 (0.34) PDK2PDK4PGR
SCHEMBL28849969 0.69 PDK2 (0.36) PDK2PDK4
SCHEMBL30338892 0.69 PDK2 (0.36) PDK2PDK4
Ammonia Solution, Strong SCHEMBL7083566 0.68 PDK2 (0.33) PDK2PDK4PGR
SCHEMBL12962759 0.68 PDK2 (0.33) PDK2PDK4
SCHEMBL16360047 0.68 HTR2A (0.35) PDK2PDK4
SCHEMBL10700103 0.68 PDK2 (0.33) PDK2PDK4
SCHEMBL10968620 0.68 LMNA (0.35) PDK2PDK4
SCHEMBL3840496 0.67 MAOA (0.44) PDK2PDK4PGRHCAR2
SCHEMBL4235643 0.67 PDK2 (0.41) PDK2PDK4PGRPDK1PDK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114105837-A Synthesis and application of molecules containing alkenyl sulfonyl 中国科学院上海有机化学研究所 2022-03-01 CN disclosed