SCHEMBL28850367

SCHEMBL28850367

C#CC(=O)OCc1cccc(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.56
MMP1 P03956 1/20 0.52
MMP2 P08253 1/20 0.52
MMP9 P14780 1/20 0.52
MMP12 P39900 1/20 0.52
MAOB P27338 4/20 0.50
MAOA P21397 3/20 0.50
CYP3A4 P08684 2/20 0.50
IDO1 P14902 2/20 0.50
AGXT P21549 2/20 0.50
RXRA P19793 1/20 0.49
RXRB P28702 1/20 0.49
RXRG P48443 1/20 0.49
ALDH1A1 P00352 2/20 0.48
KDM4E B2RXH2 1/20 0.48
TSHR P16473 1/20 0.48
NR4A2 P43354 1/20 0.48
HTT P42858 1/20 0.46
HPGD P15428 1/20 0.46
ALOX5 P09917 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27577784 0.81 HCAR2 (0.64) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28850250 0.81 HCAR2 (0.56) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28850295 0.81 MAOB (0.51) MMP2MMP9MMP12MAOBMAOA
SCHEMBL28850303 0.81 HCAR2 (0.56) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL134801 0.80 ALDH1A1 (0.63) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL28124409 0.80 P2RX4 (0.47) MMP1MMP2MMP9MMP12MAOB
SCHEMBL907611 0.79 ALDH1A1 (0.57) HCAR2ALDH1A1TSHR
SCHEMBL2659547 0.78 ALDH1A1 (0.61) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL7659252 0.78 HCAR2 (0.60) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL30542088 0.77 KMT2A (0.45) HCAR2ALDH1A1KDM4ETSHRTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114105806-A Novel acetylenic acid ester and acetylenic amide plant antibacterial agent 西北农林科技大学 2022-03-01 CN disclosed