SCHEMBL7659252

SCHEMBL7659252

NC(=O)OCc1cccc(Cl)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.60
CYP3A4 P08684 2/20 0.59
IDO1 P14902 2/20 0.59
AGXT P21549 2/20 0.59
MMP1 P03956 1/20 0.56
MMP2 P08253 1/20 0.56
MMP9 P14780 1/20 0.56
MMP12 P39900 1/20 0.56
RXRA P19793 1/20 0.53
RXRB P28702 1/20 0.53
RXRG P48443 1/20 0.53
HTR3E A5X5Y0 2/20 0.51
HTR3B O95264 2/20 0.51
HTR3A P46098 2/20 0.51
HTR3D Q70Z44 2/20 0.51
HTR3C Q8WXA8 2/20 0.51
MAOB P27338 3/20 0.51
MAOA P21397 2/20 0.51
NR4A2 P43354 1/20 0.51
ALDH1A1 P00352 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9677464 0.87 LMNA (0.48) HCAR2MAOBALDH1A1
SCHEMBL27577784 0.85 HCAR2 (0.64) HCAR2CYP3A4IDO1AGXTMMP1
Benzyl Carbamate SCHEMBL27573735 0.84 ALDH1A1 (0.58) HCAR2CYP3A4ALDH1A1
SCHEMBL134801 0.84 ALDH1A1 (0.63) HCAR2CYP3A4IDO1AGXTMMP1
SCHEMBL16244351 0.83 HTR3E (0.54) HCAR2CYP3A4IDO1AGXTHTR3E
SCHEMBL31139242 0.82 ALDH1A1 (0.43) HCAR2MMP1MMP2MMP9MMP12
SCHEMBL2659547 0.82 ALDH1A1 (0.61) HCAR2CYP3A4IDO1AGXTMMP1
SCHEMBL351905 0.81 IDO1 (0.54) HCAR2IDO1HTR3EHTR3BHTR3A
SCHEMBL22469951 0.81 MRGPRX4 (0.68) ALDH1A1HTTHPGD
SCHEMBL20109593 0.80 ENPP2 (0.52) CYP3A4ALDH1A1PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117396473-A Imidazopyridinyl inhibitors of plasma kallikrein 武田药品工业株式会社 2024-01-12 CN disclosed
CN-115698035-A Inhibitors of norovirus and coronavirus replication 共晶制药公司 2023-02-03 CN disclosed
WO-2022197755-A1 IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2022-09-22 WO disclosed
WO-2021188620-A1 PEPTIDOMIMETIC N5-METHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE DERIVATIVES, TRIAZASPIRO[4.14]NONADECANE DERIVATIVES AND SIMILAR COMPOUNDS AS INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION COCRYSTAL PHARMA INC. (US) 2021-09-23 WO disclosed
CN-111479806-A D-amino acid oxidase inhibitors and therapeutic uses thereof 心悦生医股份有限公司 2020-07-31 CN disclosed
CN-111263758-A Branched multifunctional macromers and related polymers and uses thereof 麻省理工学院 2020-06-09 CN disclosed
CN-110073005-A Method for detecting norovirus 奎斯特诊断投资有限责任公司 2019-07-30 CN disclosed
US-6462076-B2 CYSTEINE PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CYSTEINE PROTEASES, SUCH AS OSTEOPOROSIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, TUMOR METASTASIS, ANGINA PECTORIS, PLAQUE RUPTURE AND STROKE ETC. HOFFMANN-LA ROCHE INC. 2002-10-08 US disclosed