Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28625554 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EL3MBTL1POLB | |
| SCHEMBL2237187 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAGSK3AGSK3B | |
| SCHEMBL19964926 | 0.78 | TRIM24 (0.47) | ALDH1A1MAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL28331384 | 0.76 | TRIM24 (0.48) | ALDH1A1MAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL8772644 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAKDM4EL3MBTL1 | |
| SCHEMBL2831481 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAGSK3AGSK3B | |
| SCHEMBL1126803 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNAKDM4EL3MBTL1 | |
| SCHEMBL8377839 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL5180011 | 0.75 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAGSK3AGSK3B | |
| SCHEMBL29295631 | 0.75 | ALDH1A1 (0.43) | ALDH1A1MAPTLMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715634-B | Fused bicyclic inhibitors of MENIN-MLL interaction | 詹森药业有限公司 | 2022-09-27 | — | — | CN | disclosed |