Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7556949 | 0.88 | CHRM4 (0.61) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL15379133 | 0.87 | NOS2 (0.54) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL8317190 | 0.85 | NOS2 (0.58) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL7504527 | 0.84 | ALDH1A1 (0.60) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL7284050 | 0.83 | OPRM1 (0.58) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL4159590 | 0.83 | NOS2 (0.58) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL2878327 | 0.81 | NOS2 (0.54) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL29995634 | 0.81 | NOS2 (0.54) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL29087312 | 0.81 | NOS2 (0.54) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 | |
| SCHEMBL10566099 | 0.80 | MEN1 (0.53) | NOS2OPRK1OPRD1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MC1R, MCHR1, MCHR2 | NOS2 3160/4885OPRK1 41/4885OPRD1 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.