Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29039165 | 1.00 | PPARA (0.55) | PPARAEPHX2FAAHTRPV1GMNN | |
| Sulfuric Acid SCHEMBL27878981 | 0.94 | PPARA (0.52) | PPARAEPHX2FAAHTRPV1GMNN | |
| Sulfuric Acid SCHEMBL10684011 | 0.94 | PPARA (0.52) | PPARAEPHX2FAAHTRPV1GMNN | |
| Sulfuric Acid SCHEMBL28011892 | 0.92 | PPARA (0.50) | PPARAEPHX2FAAHTRPV1GMNN | |
| Sulfuric Acid SCHEMBL10684008 | 0.88 | EPHX2 (0.49) | PPARAEPHX2FAAHTRPV1 | |
| SCHEMBL23673187 | 0.87 | FAAH (0.54) | PPARAFAAHTRPV1GMNNUSP2 | |
| SCHEMBL20508017 | 0.87 | FAAH (0.54) | PPARAFAAHTRPV1GMNNUSP2 | |
| SCHEMBL20508156 | 0.87 | FAAH (0.54) | PPARAFAAHTRPV1GMNNUSP2 | |
| SCHEMBL20503136 | 0.87 | FAAH (0.54) | PPARAFAAHTRPV1GMNNUSP2 | |
| SCHEMBL20508155 | 0.87 | FAAH (0.54) | PPARAFAAHTRPV1GMNNUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107427531-A | Lipid nanoparticle containing nucleic acid | 协和发酵麒麟株式会社 | 2017-12-01 | — | — | CN | disclosed |