Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968990 | 0.81 | KMT2A (0.42) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL7958916 | 0.81 | TRPV3 (0.45) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL6409488 | 0.81 | ADRB2 (0.46) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL27135558 | 0.81 | MAPT (0.42) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL5139622 | 0.80 | IDH1 (0.41) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL27775433 | 0.80 | PIK3CA (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3260707 | 0.79 | NR1H2 (0.46) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL4101559 | 0.78 | SREBF2 (0.48) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL14351990 | 0.78 | HRH1 (0.48) | MAPTKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL2639519 | 0.78 | NPC1 (0.42) | MAPTKMT2AKDM4EMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640869-B | Imidazo thiadiazoles and Imidazopyridazine derivative as proteinase activated receptors 4 (PAR4) inhibitor for treating platelet aggregation | 百时美施贵宝公司 | 2017-12-12 | — | — | CN | disclosed |