Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28208711 | 0.90 | KCNH2 (0.44) | SREBF2CTSKKDM4EL3MBTL1MAPT | |
| SCHEMBL7468603 | 0.88 | KCNH2 (0.51) | SREBF2KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL11298035 | 0.87 | KCNH2 (0.54) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL27135558 | 0.85 | MAPT (0.42) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL7910500 | 0.83 | SREBF2 (0.50) | SREBF2KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL14351990 | 0.82 | HRH1 (0.48) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL25972174 | 0.79 | KDM4E (0.50) | KDM4EL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL6409488 | 0.78 | ADRB2 (0.46) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL28853231 | 0.78 | MAPT (0.42) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL7958916 | 0.78 | TRPV3 (0.45) | KDM4EL3MBTL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008030369-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |