Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745795 | 0.87 | PTGS2 (0.53) | PTGS2CYP19A1CYP2A6AHRPIP4K2A | |
| SCHEMBL9269708 | 0.84 | HDAC1 (0.51) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL1650349 | 0.84 | CA12 (0.49) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL8990514 | 0.83 | EPHX2 (0.53) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL1275476 | 0.83 | HDAC1 (0.48) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL9800386 | 0.83 | HDAC1 (0.45) | PTGS2HDAC1HDAC8CYP19A1CA12 | |
| SCHEMBL8666600 | 0.80 | HDAC1 (0.55) | HDAC1HDAC8CYP19A1CA1CA2 | |
| SCHEMBL9772878 | 0.80 | HDAC1 (0.48) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL1457933 | 0.79 | CYP19A1 (0.48) | HDAC1HDAC8CYP19A1CA12CA1 | |
| SCHEMBL4414373 | 0.78 | HDAC1 (0.52) | HDAC1HDAC8CYP19A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105392787-B | For treating and preventing the azepine oxindole of respiratory syncytial virus infection | 豪夫迈·罗氏有限公司 | 2017-11-24 | — | — | CN | claimed |
| CN-105392787-B | For treating and preventing the azepine oxindole of respiratory syncytial virus infection | 豪夫迈·罗氏有限公司 | 2017-11-24 | — | — | CN | disclosed |