Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSH | P09668 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 4/20 | 0.43 |
| ▸ | GSR | P00390 | 3/20 | 0.43 |
| ▸ | DTYMK | P23919 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10705051 | 0.80 | CTSB (0.68) | MAPTTDP1POLBL3MBTL1CTSB | |
| SCHEMBL34472362 | 0.77 | CTSB (0.44) | MAPTTDP1POLBL3MBTL1CTSB | |
| SCHEMBL28191905 | 0.77 | SMN1; SMN2 (0.56) | MAPTTDP1POLBL3MBTL1CTSB | |
| SCHEMBL2961445 | 0.75 | MAPT (0.66) | MAPTTDP1L3MBTL1CTSBHTT | |
| SCHEMBL29157027 | 0.74 | MAPT (0.55) | MAPTTDP1POLBL3MBTL1HTT | |
| SCHEMBL31444804 | 0.74 | MAPT (0.56) | MAPTTDP1POLBL3MBTL1CTSB | |
| SCHEMBL14529874 | 0.71 | POLB (0.49) | MAPTTDP1POLBL3MBTL1HTT | |
| SCHEMBL8065104 | 0.71 | TDP1 (0.57) | MAPTTDP1DTYMKGAACASP6 | |
| SCHEMBL1200287 | 0.70 | ALDH1A1 (0.66) | MAPTTDP1POLBL3MBTL1TXNRD1 | |
| SCHEMBL30271385 | 0.70 | MAPT (0.53) | MAPTTDP1POLBL3MBTL1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164119-B | 5-amino-quinoline-8-carboxamide derivatives as 5-HT4 receptor agonists | 苏文生命科学有限公司 | 2017-12-08 | — | — | CN | disclosed |