Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 4/20 | 0.47 |
| ▸ | GSR | P00390 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710611 | 1.00 | MAPT (0.53) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL29364858 | 0.81 | MAPT (0.50) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL56616 | 0.81 | MAPT (0.50) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL6990761 | 0.79 | MAPT (0.49) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL17434625 | 0.79 | MAPT (0.49) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL9669573 | 0.78 | GPR35 (0.46) | MAPTTDP1L3MBTL1HTTTSHR | |
| SCHEMBL11409567 | 0.78 | MAPT (0.47) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL3273393 | 0.78 | TXNRD1 (0.50) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL29392605 | 0.78 | MERTK (0.51) | MAPTTDP1POLBL3MBTL1MERTK | |
| SCHEMBL381701 | 0.78 | MERTK (0.51) | MAPTTDP1POLBL3MBTL1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380560-A1 | LPAR1 ANTAGONISTS AND USES THEREOF | Contineum Therapeutics, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023014908-A1 | LPAR1 ANTAGONISTS AND USES THEREOF | Pipeline Therapeutics, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |