Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28196751 | 0.82 | RAF1 (0.46) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL11692597 | 0.78 | ALDH1A1 (0.45) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL28197504 | 0.77 | POLB (0.49) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28197567 | 0.76 | RAF1 (0.47) | RAF1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL1694410 | 0.74 | DAO (0.52) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL28196781 | 0.74 | RAF1 (0.45) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL28196767 | 0.72 | GAA (0.54) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL11471040 | 0.72 | HSD17B10 (0.48) | RAF1GAAMEN1KMT2AHSD17B10 | |
| SCHEMBL8031103 | 0.71 | TSHR (0.44) | RAF1GAAMEN1KMT2ATP53 | |
| SCHEMBL6492551 | 0.71 | RAF1 (0.45) | RAF1GAATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107646035-A | Heterocyclyl methyl thieno uracil as adenosine A 2B receptor antagonists | 拜耳制药股份公司 | 2018-01-30 | — | — | CN | disclosed |