Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857585 | 0.88 | LMNA (0.66) | LMNAPOLBGAARAB9ACYP3A4 | |
| SCHEMBL28857626 | 0.88 | PTGDR2 (0.58) | LMNAPOLBGAARAB9ACYP3A4 | |
| SCHEMBL28857612 | 0.87 | GAA (0.57) | LMNAPOLBGAARAB9ACYP3A4 | |
| SCHEMBL28857646 | 0.84 | LMNA (1.00) | LMNAPOLBGAAHTTSMN1; SMN2 | |
| SCHEMBL28955070 | 0.81 | LMNA (0.64) | LMNAPOLBRAB9ACYP3A4MAPT | |
| SCHEMBL28857580 | 0.80 | LMNA (0.66) | LMNAPOLBGAARAB9AMAPT | |
| SCHEMBL213450 | 0.79 | HDAC1 (0.60) | LMNAGAARAB9ACYP3A4MAPT | |
| SCHEMBL28857591 | 0.78 | HIF1A (0.60) | LMNAPOLBGAARAB9AMAPT | |
| SCHEMBL31462454 | 0.76 | LMNA (0.62) | LMNAPOLBGAARAB9ACYP3A4 | |
| SCHEMBL28857636 | 0.76 | LMNA (0.81) | LMNAPOLBGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | claimed |
| CN-115160269-A | Arylcarboxamide derivatives as positive allosteric modulators of NMDAR | 北京大学 | 2022-10-11 | — | — | CN | disclosed |