Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 4/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | PLD2 | O14939 | 1/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30314640 | 0.88 | HRH4 (0.58) | P2RY14HRH4PLD2PLD1MMP2 | |
| SCHEMBL28208771 | 0.84 | KDM4E (0.55) | HPNHRH4MMP2MMP13MMP14 | |
| SCHEMBL28207999 | 0.82 | KDM4E (0.60) | MMP2MMP13MMP14ABCB1CHEK2 | |
| SCHEMBL26306635 | 0.79 | HRH4 (0.46) | P2RY14HRH4SLC6A2PLD2PLD1 | |
| SCHEMBL333745 | 0.79 | MMP13 (0.74) | MMP2MMP13MMP14KDM4EGAA | |
| SCHEMBL29619366 | 0.79 | P2RY14 (0.50) | P2RY14HRH4PLD2PLD1PARP1 | |
| SCHEMBL11552360 | 0.78 | HRH4 (0.45) | P2RY14HRH4PLD2PLD1MMP2 | |
| SCHEMBL22525900 | 0.76 | PTPN1 (0.54) | P2RY14HRH4PLD2PLD1KDM4E | |
| SCHEMBL13554437 | 0.76 | MMP2 (0.46) | HRH4MMP2MMP13KIF11KDM4E | |
| SCHEMBL16599412 | 0.75 | HRH4 (0.60) | HRH4PLD2PLD1KDM4EPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555763-B | indole-carboxamide derivatives | 豪夫迈·罗氏有限公司 | 2018-04-17 | — | — | CN | claimed |
| CN-105555763-B | indole-carboxamide derivatives | 豪夫迈·罗氏有限公司 | 2018-04-17 | — | — | CN | disclosed |