Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28207112 | 0.94 | GSR (0.67) | GSRARG2ARG1ITGB3ITGA2B | |
| Lysine SCHEMBL3868637 | 0.94 | GSR (0.67) | GSRARG2ARG1ITGB3ITGA2B | |
| Lysine SCHEMBL28207684 | 0.86 | GSR (0.47) | GSRARG2ARG1ITGB3ITGA2B | |
| Lysine SCHEMBL27895772 | 0.82 | GSR (0.87) | GSRARG2ARG1RNPEPCPB2 | |
| Lysine SCHEMBL27881240 | 0.82 | GSR (0.87) | GSRARG2ARG1RNPEPCPB2 | |
| Lysine SCHEMBL28207652 | 0.81 | GSR (0.50) | GSRARG2ARG1ITGB3ITGA2B | |
| Lysine SCHEMBL28980842 | 0.79 | GSR (0.74) | GSRARG2ARG1RNPEPPOLB | |
| Lysine SCHEMBL28980840 | 0.79 | GSR (0.74) | GSRARG2ARG1RNPEPPOLB | |
| Lysine SCHEMBL29075874 | 0.79 | GSR (0.95) | GSRARG2ARG1RNPEPCPB2 | |
| Lysine SCHEMBL27897514 | 0.79 | GSR (0.95) | GSRARG2ARG1RNPEPCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108129652-A | A kind of polyethylene glycol lysine maleimide thioguanine conjugate | 湖南华腾制药有限公司 | 2018-06-08 | — | — | CN | claimed |