Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 18/20 | 0.71 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27589 | 0.82 | HPGDS (1.00) | HPGDSCRBN | |
| SCHEMBL27841 | 0.81 | HPGDS (1.00) | HPGDSCRBNCYP3A4USP2ALDH1A1 | |
| SCHEMBL27787 | 0.81 | HPGDS (1.00) | HPGDSCRBN | |
| SCHEMBL29363 | 0.79 | HPGDS (1.00) | HPGDSCRBN | |
| SCHEMBL23017395 | 0.77 | HPGDS (0.73) | HPGDSCRBNCYP3A4USP2ALDH1A1 | |
| SCHEMBL28492 | 0.76 | HPGDS (0.81) | HPGDSCRBN | |
| SCHEMBL28314 | 0.76 | HPGDS (0.73) | HPGDSCRBNCYP3A4 | |
| SCHEMBL28315 | 0.75 | HPGDS (1.00) | HPGDSCRBNCYP3A4 | |
| SCHEMBL9998846 | 0.75 | HPGDS (1.00) | HPGDSCRBN | |
| SCHEMBL28862 | 0.74 | HPGDS (0.54) | HPGDSCYP3A4USP2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407466-A1 | PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE | Taiho Pharmaceutical Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |